Medical Research Future Fund – National Critical Research Infrastructure Initiative – 2023 Innovative Trials

Overview

This grant opportunity is part of the MRFF’s National Critical Research Infrastructure Initiative. NCRI provides funding through multiple streams to establish and extend infrastructure (facilities, equipment, systems and services) of critical importance that will be used to conduct world-class health and medical research. Within the NCRI innovation enablers stream, this grant opportunity will provide grants of financial assistance to support Australian medical research and innovation projects that: Stream 1: address an area of unmet medical need by promoting the development and implementation of adaptive platform trials. Research proposals in this stream must focus on one of the following topics: Topic A: conducting inception projects that build evidence and capability to demonstrate the feasibility of establishing a national adaptive platform trial that would allow for rapid assessment of pharmacological and/or non-pharmacological interventions in an area of unmet need Topic B: establishing a new national adaptive platform trial that addresses an area of unmet need, including set up of central infrastructure and conduct of initial launch domains Topic C: expanding an existing adaptive platform trial by adding new domains that address an area of unmet need. Stream 2: conduct a registry-based randomised controlled trial in an area of unmet medical need by embedding a registry-based randomised controlled trial into a pre-existing clinical registry Stream 3: generate evidence of the efficiency and cost effectiveness of innovative trial designs over conventional trial designs for: Topic A: adaptive platform trials Topic B: registry-based randomised controlled trials.